Koi CBD Review

Our Rating: A. Innovate products and flavors with verified levels of CBD.
Koi CBD oil is a high-quality oil with guaranteed therapeutic concentrations of CBD. Their lab analyses check out in our research. Even though they include products like vape and gummies, their products actually contain therapeutic levels of CBD, a rarity in the industry. With cookie-cutter CBD companies, all franchises of one old hemp manufacturer, only the 25% oil and the concentrates actually have therapeutic levels of CBD. Not so with Koi. You can get enough CBD from grape vape or strawberry gummies with Koi. You don’t have to choose between fun or getting the CBD you need for stress and anxiety associated with various medical conditions. These products also contain the ‘entourage’ cannabinoids and terpenes like CBDV, CBG, limonene, and myrcene. We will focus on Koi Full Spectrum CBD oil but also go over information about the other products.

Figure 1.
CBD oil can be used under the tongue or added to foods. It may be dissolved in hemp oil or coconut oil. This adds healthy fatty acids and MCTs to the mix. Koi produces CBD tinctures, vapes, topicals, supplements, gummies, and even pet products. Koi provides CBD in various flavors. None of these products will make you high. They are meant as dietary supplements.

Koi sources its hemp from the San Luis Valley between Colorado and New Mexico. This is an arid, sunny region between the valley and the headwaters of the river called the Rio Grande. In this environment, hemp grows resilient, lush, and packed with cannabinoids and terpenes.

Koi hemp oil

Is its CBD oil?	Yes. It is both CBD oil and hemp oil.
Old, the trusted company?	No. Operating since 2015.
Contains verified therapeutic levels of CBD?	Yes.
Sourced in the United States?	Yes.
Sourced in Europe?	No.
Certified Organic in the US?	Unknown.
Certified Organic by the European Commission?	Unknown.
Did the lab test in the United States?	Yes.
3rd Party Testing?	Yes.
Do they tell what percentage CBD in a product?	Yes.
CO2 extracted?	No. Solvent-free extraction.
GMO-free?	Yes.
Pesticide-free?	Yes.
Functional Website?	Yes. High function.

From our grading questions above and our research, Koi CBD products get an A. If you have any suspicions about their products, send a sample of the product to a 3^rd party lab and leave a comment telling us your results.

Advantages of Koi Hemp Oil

The advantage of Koi Hemp products is that they provide guaranteed therapeutic levels of CBD in innovative and delicious products. With most companies, you can either have therapeutic levels of CBD, or you can have cool products with cheap hemp oil in them and little CBD.

Koi Vape products actually deliver a therapeutic level of CBD via vape. Most vape products will not deliver you a therapeutic dose even if you vape all day long. Koi has done the math and has the lab analyses to prove it. Even their Tropical Gummies has 10 mg of CBD per gummy!  That is unheard of for CBD gummy candies, most of which just have hemp seed oil in them. The hemp seed oil has less than 25 parts per million of CBD.

One potential disadvantage of Koi is that they use a solvent-free extraction process for their CBD. We simply don’t know what this method is or if it produces a product of the caliber of supercritical CO2 extraction, or if it is worse or better. CO2 is the same stuff you breathe out, we know it’s fairly safe to use. Whatever method they use, we don’t know if it is more or less safe than CO2 extraction.

Lab Analyses

Koi CBD uses the Confident Cannabis lab result reporting system to report lab results for each batch of the product tested by the CannaSafe Labs. Get it?  Confident Cannabis handles the lab reporting, CannaSafe laboratories do the testing. We will assume this is a third-party lab. And the lab results are very good, even for the vape products.

Koi prices and products

Details

Koi Naturals Full-Spectrum CBD Oil

8.5 mg to 34 mg of CBD per dropper.

5 mg to 2 mg of CBD per drop.

INGREDIENTS: coconut oil, Koi PRIZM™ full-spectrum CBD oil, natural orange flavor extract.

Directions: Consume a complete dropper (1mL or 30 drops), from one to three times daily.  Hold under the tongue for 15–20 seconds, then swallow. Wait three hours after initial (first time) use to see how the strength level of CBD may affect you.

Koi CBD Vape Juice

Ingredients: 100% natural cannabidiol (CBD) isolate, food-grade vegetable glycerin, propylene glycol, natural & artificial flavorings

Made with 100% natural CBD, with full traceability from the start of extraction

A 3mL vape tank will hold 102 mg of CBD. This is one of the few vape products which clearly shows that you can get therapeutic levels of CBD through vaping. However, it has not been proven that vaping is an effective way to take the CBD.

Koi Lavender

200 mg of CBD

Ingredients: organic aloe leaf juice, organic coconut oil, glycerin, emulsifying wax NF, stearic acid, organic jojoba seed oil, witch hazel water, organic alcohol extract, vitamin e oil, organic neem seed oil, rosemary leaf extract, Phenoxyethanol, rose distillate, lavender essential oil, organic white willow bark, xanthan gum, Tetrasodium EDTA, naturally occurring CBD in hemp oil.

What are the Main Ingredients for Koi Products?

The main ingredient is Koi CBD isolate or Koi PRIZM full-spectrum CBD blend which is created using a solvent-free method of extraction.

Products may also contain Koi CBD, terpenes, Koi Hemp oil, and/or CBD concentrates. CBD is cannabidiol, the main cannabinoid which produces most of the therapeutic effects by affecting cannabinoid receptors throughout the central nervous system. Terpenes provide fragrance, flavor, and boosts the effects of CBD. CBD Hemp oil drops are the combination of hemp seed oil with CBD isolate from CBD-Rich Whole Hemp Plant Extract.

How to Use

Vaping

Koi has vape products that have therapeutic CBD levels. These are the first vape products we have seen to provide certificates of analysis showing that there are therapeutic CBD levels.

Edibles

Koi specializes in flavorful edibles like gummies and flavored hemp oils which can be added to food or used under the tongue.

Sublingual

Koi’s CBD hemp oil drops can be used sublingually.

Topical application

Koi Lavender is a lotion with therapeutic levels of CBD which can be applied as needed.

Tinctures

Koi CBD oil drops are an oil tincture that can be eaten with food or applied under the tongue.

Dosage

Koi Naturals Full-Spectrum CBD Oil

One drop contains about 2 mg of CBD

For chronic pain, you might take 20 mg per day or 10 drops.

For non-medical anxiety in people who have epilepsy, up to 300 mg or 150 drops in divided doses throughout the day.

For the inability to sleep well at night, 20 drops, or 40 mg before bedtime daily.

For stress and tension in a person who has Huntington’s disease, 10 mg per kilogram of body weight, or 5 drops per kilogram of body weight.

For stress and tension in a person who has schizophrenia, up to 1,280 mg or 640 drops per day.

For glaucoma, absolutely no more than 40 mg or 20 drops per day. Higher doses can worsen symptoms.

Koi CBD Vape Juice

250mg CBD – 30mLBottleOne standard dropper holds about 10 mg of CBD from Koi Vape Juice. Therefore, a typical beginning dose for anxiety may be about 40 mg or four droppers in divided doses. For chronic pain, you might take 20 mg per day or 2 droppers. For non-medical anxiety in people who have epilepsy, up to 300 mg or 30 droppers in divided doses throughout the day. For the inability to sleep well at night, 4 droppers, or 40 mg before bedtime daily. For stress and tension in a person who has Huntington’s disease, 10 mg per kilogram of body weight, or one dropper per kilogram of body weight.For stress and tension in a person who has schizophrenia, up to 1,280 mg or 128 droppers per day.

For glaucoma, absolutely no more than 40 mg or 4 droppers per day. Higher doses can worsen symptoms.  

Koi Lavender

Use a dime-sized amount to start, then gradually increase the dose until you get the desired effects. Use as much or as little as required.

Manufacturer, Support, Certificates

Koi CBD
Address	14631 Best Ave. Norwalk, CA 90650
Phone	+ 1-877- 774-4779
Email	[email protected]
Contact	https://koicbd.com/contact-us/

25% discount on all products to active duty and U.S. military veterans.

Pros and cons

Koi CBD Oil reviews

Review Rating: A.  “It’s been wonderful.”

This reviewer in a Facebook group for Ehlers-Danlos syndrome said that Koi CBD oil has worked for her headaches, pain, and inflammation.

Review Rating: C. “Less effective…”

This Facebook reviewer switched to Koi CBD and found it less effective than his previous brand in helping to calm a 5-year-old with socially activated symptoms of ADHD.

Review Rating: A

This Facebook reviewer finds Koi CBD effective for anxiety.

Review Rating: A. “…the only one that worked…”

This Facebook reviewer found Koi vape juice to be the only vape that has worked; however, he feels that it is somewhat pricey.

Review Rating: A. “made me feel relaxed…”

This Reddit user finds Koi vape to be effective for fighting anxiety.

Q&A about Koi CBD

Conclusion

Grade:  A

Koi CBD oil and other Koi products seem to be very well made. They post lab results for each batch and list the CBD concentrations per bottle and per serving. This is unique among companies. Most companies leave you to do the math yourself so that you don’t find out you will have to vape 3 full bottles to get one sufficient dose of CBD. With Koi vape, a normal amount can get you a therapeutic amount of CBD. And they also have tasty flavors and great label designs. So, it seems they really did their homework, used their in house lab, then sent it to a 3^rd party lab.

CBD oil disclaimers (please read, this is important):

General Medical Disclaimer

Leaf Expert and its employees and partners do not represent the medical establishment and our information is not a replacement for your doctor’s advice.

Food and Drug Administration Disclaimer

The use of CBD products with the exception of Epidiolex and Sativex has not been evaluated or approved by the FDA.  These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

Drug Screening Disclaimer

While most CBD products claim to have little to no THC, it is theoretically possible to fail a drug test for THC. This can happen because some CBD products have been tested to have far more THC than represented on the label. Also, CBD is similar in structure to THC.

About CBD and CBD-A

How it Works (scientific research)

Koi’s products have cannabidiol as the main active ingredient. Cannabidiol is known to have many mechanisms of action. We list the receptors in the central nervous system which cannabidiol binds to below. These include cannabinoid receptors, serotonin receptors, and orphan receptors which are related to cannabinoid receptors by their structure. CBD also modulates opioid receptors by which it affects pain perception. These are not the only receptors cannabidiol may bind to or effect.

Cannabidiolic acid (CBDa) have been shown to have the following effects:

• Fighting nausea (Rock, Limebeer, & Parker, Effect of combined doses of Δ 9 -tetrahydrocannabinol (THC) and cannabidiol acid (CBDA) on acute and anticipatory nausea using rat (Sprague- Dawley) models of conditioned gaping, 2015)
• Breast Cancer growth inhibitor (Takeda, et al., 2012)
• Anxiety fighter (Pertwee, et al., 2018)
• Vomiting fighter (Bolognini, et al., 2013)
• Depression fighter (Hen-Shoval, et al., 2018)
• Diarrhea fighter (Cluny, et al., 2011)
• Studied for inflammatory pain (Rock, Limebeer, & Parker, Effect of cannabidiolic acid and ∆9-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain., 2018)

Cannabidiol (CBD) has been shown to have the following health benefits:

• Anti-cancer (Massi, Solinas, Cinquina, & Parolaro, 2013).
• Anti-infarction (Hayakawa, et al., 2004).
• Anti-psychotic (Iseger, Bossong, & Bossong, 2015).
• Anti-seizure activity, known about in 1973 (Izquierdo, Orsingher, & Berardi, 1973).
• Attenuates the adverse effects of THC (Henquet & Kuepper, 2010).
• Can fight memory loss caused by marijuana THC(Morgan, Schafer, Freeman, & Curran, 2010). This means that medical marijuana should be enriched with extra cannabidiol to avoid memory loss and psychotic effects
• Fights cerebral infarction by modulating serotonin (Mishima, et al., 2005).
• Fights migration of cancer cells (Kapoor, 2013).
• Fights myocardial ischemia-reperfusion injury (Durst, et al., 2007).
• Inhibiting angiogenesis feeds cancers (Solinas, et al., 2012).
• May fight autoimmune diabetes (Weiss, et al., Cannabidiol arrests the onset of autoimmune diabetes in NOD mice, 2008)
• May fight colon cancer (Aviello, et al., 2012).
• May fight neurodegeneration (Iuvone, Esposito, Filippis, Scuderi, & Steardo, 2009).
• May help in colitis (Borrelli, et al., 2009).
• May reduce immune system inflammatory responses (Kozela, et al., 2010).
• Modulates sleep (Murillo-Rodríguez, Millán-Aldaco, Palomero-Rivero, Mechoulam, & Drucker-Colín, 2006).
• Neuroprotective (Hampson, Grimaldi, Axelrod, & Wink, 1998).
• Prevents diabetes (Weiss, et al., Cannabidiol lowers the incidence of diabetes in non-obese diabetic mice, 2006)
• Reduces anxiety in the right doses (Fusar-Poli, et al., 2009).
• Vasorelaxation (Stanley, Hind, Tufarelli, & O’Sullivan, 2015).
• Wakefulness-promoting, modulation of circadian rhythms (Murillo-Rodríguez, et al., 2014).

Cannabidiol and cannabidiolic acid work by binding to various receptor targets throughout the central nervous system and the rest of the body. Acting at these receptor sites, it exerts influence on the metabolism of various neurotransmitter systems. It seems like ‘snake oil’ that one compound can have all the beneficial effects listed above; however, cannabinoid receptors exist throughout the nervous system and it is known that such a ubiquitous receptor must be involved in nearly everything the nervous system does, just like serotonin and dopamine receptors. Dopamine affects pleasure, but also pain. Anxiety and also relaxation. Heart contraction and blood pressure. All of these systems are integrated so cannabinoid receptors will indeed have effects on all of these systems and exogenous cannabinoids from plants can definitely have therapeutic effects that are extensive.

Mechanisms of action of CBD

1. CB1 receptor agonist
2. CB2 receptor agonist
3. Glitazone receptor agonist
4. GPR12 (inverse agonist)
5. GPR3 (inverse agonist)
6. GPR55 (antagonist) receptors
7. GPR6 (inverse agonist)
8. Inhibitor of fatty acid amide hydrolase, increasing levels of endogenous cannabinoids
9. Serotonin 5-HT1A receptor partial agonist
10. An allosteric modulator of mu and sigma opioid receptors (Kathmann, Flau, Redmer, Tränkle, & Schlicker, 2006)

The action of CBD and CBDa produces anti-inflammatory, anti-pain, and anti-seizure effects which can help relieve stress in a range of discomforting conditions.

Does CBD have any side effects?

CBD is unlikely to have many side effects under 300 mg daily. Above that dosage, one should consult a doctor.

Before we look at the side effects, let’s look at the safety. Consider these facts:

CBD Safety facts

1. Does not induce changes in food intake
2. Does not induce catalepsy
3. CBD is non-toxic
4. Does not affect physiological parameters such as:
   • Heart rate
   • Blood pressure
   • Body temperature
5. Does not affect gastrointestinal movement
6. Does not alter the psychomotor function
7. It does not alter psychological functions.
8. Chronic use and high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.

(Bergamaschi, Queiroz, Zuardi, & Crippa, 2011)
Now, here are the side effects which have been reported:

Possible Negative Side Effects of CBD

1. Tiredness
2. Inhibition of hepatic drug metabolism (possible drug interactions)
3. Decreased fertilization capacity
4. Decreased activities of p-glycoprotein and other drug transporters
5. Alterations of in vitro cell viability
6. Sleepiness
7. Poor quality sleep
8. Insomnia
9. Diarrhea
10. Decreased appetite
11. Changes in appetite

In general, CBD is safe and well-tolerated. Doses above 300 mg should have a doctor’s monitoring. Your doctor should manage drug interactions.